Long term side effects of lamictal - Tell a doctor or call 111 straight away if you have a serious side effect, including: worsening fits or seizures (if you take lamotrigine for epilepsy) unexpected bruising or bleeding, a high temperature or sore throat – these could be signs of a blood disorder

 
Summary. Common side effects of Lamictal XR include: ataxia, skin rash, headache, insomnia, and nausea. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Continue reading for a comprehensive list of adverse effects. Applies to lamotrigine: oral tablets conventional, oral tablets extended-release film .... Alicia

The initial use of lamotrigine was to treat people with depressed, manic and mixed states that did not respond to existing medications. Some patients are now being maintained on lamotrigine on a long term basis in an attempt to prevent future episodes. Evidence regarding the effectiveness of lamotrigine as a long-term prophylactic agent is ... At first I was just on abilify— a pretty high dose— and while it kept me free from hypomania, it didn’t really do much for the depression. Lamictal, on the other hand, has worked wonders in that respect. Very little side effects— I wake up nauseous but it fades after about an hour, and it’s definitely worth it.Lamotrigine and sleep issues tend to go hand-in-hand according to some scientific reports. Of course, this doesn’t mean everyone using Lamictal will automatically have insomnia. Today we’re going to look into the main Lamotrigine side effects and how it affects your sleep. Finding the right medication for any ailment is often a complicated ...Very common side effects of taking lamotrigine (affecting more than one in ten people) include: headaches; skin rashes; Common side effects of taking lamotrigine (affecting up to one in ten people) include: feeling aggressive, agitated or irritable; feeling sleepy, tired or drowsy; insomnia (having difficulty sleeping) feeling dizzy; shaking or ...I have been on Lamictal for a long time now and it helps me greatly. It had some side effects in the beginning tho. Increase in sexdrive, appetite fluxtuation, insomnia, and mild dehydration were mine. Every drug effects everybody differently tho. I haven't had any long term side effects from this drug. But Lamictal does give me low red blood cell counts, for which I take a B12 supplement. If Lamictal (or some other cause) has led to a B12 deficiency, that could explain a number of your symptoms. A B12 deficiency can cause: --weakness, tiredness or light-headedness. --rapid heartbeat and breathing.For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ...Oct 26, 2022 · These include dizziness, headache, and nausea. Other Lamictal side effects are rare but more serious. These include rash, low blood cell levels, and an increase in suicidal thoughts and behaviors. Lamictal has a boxed warning for serious, life-threatening rash. increased hair growth, especially on the face. increased in sexual ability, desire, drive, or performance. increased interest in sexual intercourse. sore gums. tenderness in the stomach area. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.Lamotrigine can also cause other side effects. More common side effects. The more common side effects that can occur with use of lamotrigine include: dizziness; drowsiness; headache; double vision ...At first I was just on abilify— a pretty high dose— and while it kept me free from hypomania, it didn’t really do much for the depression. Lamictal, on the other hand, has worked wonders in that respect. Very little side effects— I wake up nauseous but it fades after about an hour, and it’s definitely worth it. Lamotrigine (LTG) is a drug commonly used to treat epilepsy and can also be used to manage mood disorders, such as bipolar disorder. One of the most dangerous adverse effects of LTG is skin rash, which can make early cessation necessary. Here, we examine the adverse effects associated with long-term use of LTG for the treatment of mood disorders.Aug 3, 2021 · Lamotrigine did not work in acute mania; it did not work in acute bipolar depression; and it did not work in rapid cycling. But bipolar disorder (BD) is a chronic condition, and that is where the medication succeeded: in the maintenance phase. The 2 positive studies looked at lamotrigine in the long term, over 1 and a half years. The safety of using Lamictal during pregnancy has not been established. Lamictal is secreted into breast milk, and breastfeeding while taking Lamictal is not recommended. Our Lamictal Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.Add Gift Card. Check Gift Card status and balance. Our major shipping carriers have informed us to expect temporary service disruptions due to COVID-19 impacts & natural weather situations across the U.S. As a result, shipments may experience delays. Cart (6) Price. 5HSSLD21159-DPIBLUE-OS. SKU. Mar 11, 2023 · Common (1% to 10%): Arthralgia, blood creatinine phosphokinase increased/creatine phosphokinase increased, muscle rigidity, muscle spasms, muscle twitching, musculoskeletal stiffness, myalgia, pain in extremity. Uncommon (0.1% to 1%): Mobility decreased, muscle tightness, muscular weakness, musculoskeletal rigidity. increased hair growth, especially on the face. increased in sexual ability, desire, drive, or performance. increased interest in sexual intercourse. sore gums. tenderness in the stomach area. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.Aug 29, 2023 · Long-Term Side Effects of Clonidine. There is the potential for a multitude of adverse effects involving the use of clonidine. People taking the substance may experience fever, headaches, fatigue, and general weakness. More serious effects on the cardiovascular system are also possible. These effects can include heart palpitations, congestive ... Oct 31, 2014 · Many short-term side effects subside after a few weeks (once your body has gotten used to the drug). Long-term: Some individuals may take the drug for an extended period of time and be tolerating it fine, and then notice side effects that become problematic after a year or two. Usually over the long term an individual has increased their dosage ... Add Gift Card. Check Gift Card status and balance. Our major shipping carriers have informed us to expect temporary service disruptions due to COVID-19 impacts & natural weather situations across the U.S. As a result, shipments may experience delays. Cart (6) Price. 5HSSLD21159-DPIBLUE-OS. SKU.The most commonly observed side effects were dizziness, somnolence, diplopia, fatigue, nausea, vomiting, ataxia, abnormal vision, abdominal pain, tremor, dyspepsia, abnormal gait, headache, balance disorder, and asthenia. In clinical trials in children aged 1 month to 4 years, the most commonly reported side effect was somnolence.Fatigue. Nausea. Tremor. Rash. Weight gain. Most of these side effects lessen with time. Long-term effects vary from drug to drug. In general: Pregnant women should not take anticonvulsants ... Very common side effects of taking lamotrigine (affecting more than one in ten people) include: headaches; skin rashes; Common side effects of taking lamotrigine (affecting up to one in ten people) include: feeling aggressive, agitated or irritable; feeling sleepy, tired or drowsy; insomnia (having difficulty sleeping) feeling dizzy; shaking or ... Jul 25, 2022 · Lamictal rash is a possible side effect of the medication lamotrigine, which is sold under the brand name Lamictal. It can be a mild rash or a more serious rash as a result of Stevens-Johnson syndrome or toxic epidermal necrolysis. It is important to contact your doctor as soon as you experience any side effects of Lamictal, including a rash. Serious long-term side effects that Lamictal can cause include: multiorgan hypersensitivity syndrome and organ failure hemophagocytic lymphohistiocytosis (a potentially fatal immune system reaction)Took that to new provider and she explained for the first time that I was Bp2. I don't know that, that's lamictal. It takes about a week to hit your system and a bit longer to feel the full impacts, which should apply to dosages down too. I can normally get 3 or so days without it before I start to feel off.Oct 4, 2016 · That said, the side effects associated with lamotrigine may be more tolerable than side effects induced by other anxiolytic medications. As was already mentioned, lamotrigine does not appear to impair cognitive function and may even provide a modest boost in cognition. Additionally, long-term trials suggest that lamotrigine is a “weight ... Lamotrigine and sleep issues tend to go hand-in-hand according to some scientific reports. Of course, this doesn’t mean everyone using Lamictal will automatically have insomnia. Today we’re going to look into the main Lamotrigine side effects and how it affects your sleep. Finding the right medication for any ailment is often a complicated ... Oct 26, 2022 · These include dizziness, headache, and nausea. Other Lamictal side effects are rare but more serious. These include rash, low blood cell levels, and an increase in suicidal thoughts and behaviors. Lamictal has a boxed warning for serious, life-threatening rash. Aug 1, 2023 · Descriptions. Quetiapine is used alone or together with other medicines to treat bipolar disorder (depressive and manic episodes) and schizophrenia. Quetiapine extended-release tablet is also used together with other antidepressants to treat major depressive disorder. This medicine should not be used to treat behavioral problems in older adult ... Continue to take lamotrigine even if you feel well. Do not stop taking lamotrigine without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. Your doctor will probably decrease your dose gradually. If you suddenly stop taking lamotrigine, you may experience seizures.Many short-term side effects subside after a few weeks (once your body has gotten used to the drug). Long-term: Some individuals may take the drug for an extended period of time and be tolerating it fine, and then notice side effects that become problematic after a year or two. Usually over the long term an individual has increased their dosage ...At first I was just on abilify— a pretty high dose— and while it kept me free from hypomania, it didn’t really do much for the depression. Lamictal, on the other hand, has worked wonders in that respect. Very little side effects— I wake up nauseous but it fades after about an hour, and it’s definitely worth it. Basics Side effects Lamictal rash Common questions Dosage What to consider Uses Withdrawal Overdose How to take Cost Resources and support Q&A Lamictal basics If you have bipolar disorder,...Tell a doctor or call 111 straight away if you have a serious side effect, including: worsening fits or seizures (if you take lamotrigine for epilepsy) unexpected bruising or bleeding, a high temperature or sore throat – these could be signs of a blood disorderLamotrigine can also cause other side effects. More common side effects. The more common side effects that can occur with use of lamotrigine include: dizziness; drowsiness; headache; double vision ...Apr 25, 2018 · lamotrigine (Lamictal) for seizures and bipolar disorder can cause a rare but very serious reaction that excessively activates the body’s infection-fighting immune system. This can cause severe In 2 longer-term trials, the mean change in blood glucose from baseline in patients treated with this drug (mean exposure 213 days; n=646) was 5 mg/dL (vs. placebo -0.05 mg/dL). Among patients with major depressive disorder receiving the extended-release formulation of this drug, a FBG greater than 126 mg/dL occurred in 7%, 12%, and 6% of those ...Breastfeeding while taking lamotrigine: Lamotrigine can get into breast milk. Lamotrigine then gets into the baby’s body if they are breastfeeding, often at levels that are similar to the parent’s levels. Most infants who are breastfed by someone taking lamotrigine are not expected to have side effects. However, there have been case reports ...Adverse effects. Lamotrigine’s adverse effect profile is similar to placebo in all categories except sleep disruption. 1 This often presents as vivid dreams and can be minimized by dosing in the morning and using behavioral methods to deepen sleep. Other adverse effects usually improve with dose reduction. Difficulties in swallowing the ...Rarely, lurasidone can cause deadly symptoms. NMS can affect your heart, muscles, and kidneys. See your doctor right away if you get: A high fever. Stiff muscles. A change in your mood or behavior ...Geriatric Although appropriate studies on the relationship of age to the effects of lamotrigine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of lamotrigine in the elderly.Most people tolerate long-term treatment with Trileptal well and experience only mild to moderate side effects. People tend to experience the most side effects early in treatment, as the dosage is titrated up. The most commonly reported side effects are dizziness, drowsiness, changes in eyesight, upset stomach, tiredness, shaking, and headache.Jun 1, 2023 · Blistering, peeling, or loosening of the skin chills cough dark urine diarrhea fever general feeling of discomfort or illness headache itching joint pain loss of appetite memory loss muscle cramps, pain, or weakness red or irritated eyes runny nose shivering small red or purple spots on the skin ... Precautions Talk with your doctor Lamictal (lamotrigine) is a brand-name drug that’s prescribed for bipolar disorder and epilepsy. As with other drugs, Lamictal can cause side effects....Lamictal is available in generic form as lamotrigine. Lamotrigine, also known as Lamictal, is a medication used to treat several different types of seizures. Typically, it is used as an add-on medicine for adults whose partial seizures are not well controlled by another seizure medicine. Learn about Lamotrigine’s usage, side effects, and ...Mar 31, 2023 · Lamotrigine is rapidly absorbed and peak levels are reached within 1.5 to 4.8 hours of administration. The effects of lamotrigine last for over 24 hours, and once-daily dosing is often prescribed. However, some doctors prefer to split the dose to decrease the risk of side effects such as drowsiness. 7. lamotrigine (Lamictal); lithium (Eskalith, Eskalith CR, Lithobid) ... The body can develop dependence if used long term. Side effects. Side effects of stimulants include: problems with sleep; poor ...Hi, I have been on Lamictal 300mg for about 4 years. My loss of memory and inability to pull out words has gotten to the point where I'm not enjoying life. Holding a conversation that lasts a few sentences has become embarassing. I was wondering if anyone who has been on lamictal and taken off has had their memory return. I will talk to my doctor but the last time I went in they tried to ...lamotrigine (Lamictal); lithium (Eskalith, Eskalith CR, Lithobid) ... The body can develop dependence if used long term. Side effects. Side effects of stimulants include: problems with sleep; poor ...It’s used for long-term treatment of the more severe type of bipolar disorder, ... The more common side effects of Lamictal in people treated for bipolar I disorder include: nausea;Sep 13, 2021 · For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ... Jun 9, 2007 · redness of the face, neck, arms and occasionally, upper chest. shakiness and unsteady walk. sudden death. trouble concentrating. trouble sleeping. unconsciousness. unsteadiness, trembling, or other problems with muscle control or coordination. unusual paleness. Some side effects may occur that usually do not need medical attention. Traditional AEDs such as valproate and enzyme-inducing AEDs (EIAEDs) may produce high incidences of decreased libido. Recently, sexual function changes related to new AEDs have been reported. Topiramate, pregabalin and gabapentin may cause SD, whereas oxcarbazepine, lamotrigine and levetiracetam may improve sexual function.Sep 13, 2021 · For Healthcare Professionals General. The more commonly reported adverse reactions have included dizziness, headache, diplopia, ataxia, nausea,... Immunologic. In cases of hemophagocytic lymphohistiocytosis (HLH), patients have presented with signs of systemic... Hypersensitivity. Nervous system. ... Apr 14, 2023 · 4. Narcotic painkillers . 5. Sleeping aids . 6. Incontinence drugs . 7. Antihistamines (first generation) How they can affect memory: Benzodiazepines dampen activity in key parts of the brain, including those involved in the transfer of events from short-term to long-term memory. Oct 31, 2014 · Many short-term side effects subside after a few weeks (once your body has gotten used to the drug). Long-term: Some individuals may take the drug for an extended period of time and be tolerating it fine, and then notice side effects that become problematic after a year or two. Usually over the long term an individual has increased their dosage ... Lamotrigine and sleep issues tend to go hand-in-hand according to some scientific reports. Of course, this doesn’t mean everyone using Lamictal will automatically have insomnia. Today we’re going to look into the main Lamotrigine side effects and how it affects your sleep. Finding the right medication for any ailment is often a complicated ... Aug 11, 2023 · multiple swollen and inflamed skin lesions. muscle pain or stiffness. muscle tension or tightness. normal menstrual bleeding occurring earlier, possibly lasting longer than expected. numbness of the feet, hands and around mouth. pains in the stomach, side, or abdomen, possibly radiating to the back. Took that to new provider and she explained for the first time that I was Bp2. I don't know that, that's lamictal. It takes about a week to hit your system and a bit longer to feel the full impacts, which should apply to dosages down too. I can normally get 3 or so days without it before I start to feel off. Mar 20, 2023 · In 2 longer-term trials, the mean change in blood glucose from baseline in patients treated with this drug (mean exposure 213 days; n=646) was 5 mg/dL (vs. placebo -0.05 mg/dL). Among patients with major depressive disorder receiving the extended-release formulation of this drug, a FBG greater than 126 mg/dL occurred in 7%, 12%, and 6% of those ... Lamictal is available in generic form as lamotrigine. Lamotrigine, also known as Lamictal, is a medication used to treat several different types of seizures. Typically, it is used as an add-on medicine for adults whose partial seizures are not well controlled by another seizure medicine. Learn about Lamotrigine’s usage, side effects, and ...Although ophthalmological testing was performed in 1 controlled clinical trial, the testing was inadequate to exclude subtle effects or injury occurring after long-term exposure. Moreover, the capacity of available tests to detect potentially adverse consequences, if any, of lamotrigine's binding to melanin is unknown.Lamotrigine (LTG) is a drug commonly used to treat epilepsy and can also be used to manage mood disorders, such as bipolar disorder. One of the most dangerous adverse effects of LTG is skin rash, which can make early cessation necessary. Here, we examine the adverse effects associated with long-term use of LTG for the treatment of mood disorders.The Four Most Commonly Used Types of Medications That Dampen Brain Function. 1. Benzodiazepines. This class of medication is often prescribed to help people sleep, or to help with anxiety. They do work well for this purpose, but they are habit-forming and have been associated with developing dementia. Aug 11, 2023 · multiple swollen and inflamed skin lesions. muscle pain or stiffness. muscle tension or tightness. normal menstrual bleeding occurring earlier, possibly lasting longer than expected. numbness of the feet, hands and around mouth. pains in the stomach, side, or abdomen, possibly radiating to the back. Serious side effects; Other side effects; Professional info; FAQ; Applies to nystatin: oral suspension, oral tablet. Serious side effects of Nystatin. Along with its needed effects, nystatin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Other side effects of ...Many short-term side effects subside after a few weeks (once your body has gotten used to the drug). Long-term: Some individuals may take the drug for an extended period of time and be tolerating it fine, and then notice side effects that become problematic after a year or two. Usually over the long term an individual has increased their dosage ...Oct 4, 2016 · That said, the side effects associated with lamotrigine may be more tolerable than side effects induced by other anxiolytic medications. As was already mentioned, lamotrigine does not appear to impair cognitive function and may even provide a modest boost in cognition. Additionally, long-term trials suggest that lamotrigine is a “weight ... The Four Most Commonly Used Types of Medications That Dampen Brain Function. 1. Benzodiazepines. This class of medication is often prescribed to help people sleep, or to help with anxiety. They do work well for this purpose, but they are habit-forming and have been associated with developing dementia.Apr 5, 2023 · Other long-term side effects of Vraylar are possible. If you have questions about your risk of side effects from the medication, talk with your doctor. ... (Lamictal) If you have questions about ... Aug 29, 2023 · Long-Term Side Effects of Clonidine. There is the potential for a multitude of adverse effects involving the use of clonidine. People taking the substance may experience fever, headaches, fatigue, and general weakness. More serious effects on the cardiovascular system are also possible. These effects can include heart palpitations, congestive ... Precautions Talk with your doctor Lamictal (lamotrigine) is a brand-name drug that’s prescribed for bipolar disorder and epilepsy. As with other drugs, Lamictal can cause side effects....Lamotrigine and sleep issues tend to go hand-in-hand according to some scientific reports. Of course, this doesn’t mean everyone using Lamictal will automatically have insomnia. Today we’re going to look into the main Lamotrigine side effects and how it affects your sleep. Finding the right medication for any ailment is often a complicated ... Feeling poorly. Fever. Itching skin. Hives. Red blisters on areas of the body, which may include the face or mouth. Symptoms of a more serious rash can include peeling skin, painful blisters, inflammation of the eyes, swollen lymph nodes, and flu-like symptoms. The symptoms can range from benign to potentially fatal.I take lamotrigine for 1,5 years, it was added to my lithium and wellbutrin. It made me much more stable and it took the most of the depression away. It made such a difference, I can handle so much more. I still got major mood swings but I bounce back to normal much faster. And normal is longer. Mar 20, 2017 · Results. Treatment efficacy was observed at week 4, with the improved HSDS scores sustained until week 52 for all types of BP; 50% of the patients with any type of BP could be treated with LTG for 1 year, whereas ~40% could be treated for >1.5 years. However, 25% of the patients were withdrawn within the first 4 weeks. Similarly, long term risk is a subjective matter, though perhaps less so than the common immediate side effects. Lamotrigine gets a ” + +” because its main risk, the rash, was listed as an immediate side effect problem; beyond 8 weeks the rash risk falls to very low levels.To date, there are no known problems associated with long term use of lamotrigine. It is a safe and effective medication when used as directed. It is important to note that some of the side effects listed above (particularly rash and suicidal thoughts) may continue to occur or worsen if you continue taking the medication. Sep 23, 2022 · Warning. Suicidality Antidepressants may increase risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18–24 years of age) with major depressive disorder and other psychiatric disorders; balance this risk with clinical need. b c d Venlafaxine is not approved for use in pediatric patients. 1 3 (See Pediatric Use under Cautions.)

I have searched all over the net and can't find anything beyond pretty basic info on possible side effects. I have been on lamotrigine for 15 years, since the age of 15. I have small muscle twitches quite often and some memory loss. Childhood memories are very foggy. I also get a very noticeable spaced-out/disconnected feeling when I don't take .... My ps4 controller won

long term side effects of lamictal

Sep 13, 2021 · Summary. Common side effects of Lamictal ODT include: ataxia, skin rash, headache, insomnia, and nausea. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Continue reading for a comprehensive list of adverse effects. Applies to lamotrigine: oral tablets conventional, oral tablets extended-release ... Summary. Common side effects of Lamictal ODT include: ataxia, skin rash, headache, insomnia, and nausea. Other side effects include: infection, dyspepsia, abnormal gait, constipation, and drowsiness. Continue reading for a comprehensive list of adverse effects. Applies to lamotrigine: oral tablets conventional, oral tablets extended-release ...Jun 1, 2023 · Geriatric Although appropriate studies on the relationship of age to the effects of lamotrigine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of lamotrigine in the elderly. May 9, 2009 · The significant reduction in locomotion at weeks one and four suggest that anti-aging effects of lamotrigine are associated with compromised function, and in this sense a reduced health span. In conclusion, the observed decrease in mortality and increase in lifespan as a result of lamotrigine was associated with depression in locomotion and ... Serious long-term side effects that Lamictal can cause include: multiorgan hypersensitivity syndrome and organ failure hemophagocytic lymphohistiocytosis (a potentially fatal immune system reaction)hoarseness. lack or loss of strength. pain in the lower back or side. swelling of the hands, feet, or lower legs. trembling or shaking. Common side effects that do require medical attention ...Jan 24, 2016 · Mood or behavior changes, such as depression, anxiety, agitation, hostility, restlessness, mental or physical hyperactivity, suicidal thoughts. Common side effects of lamotrigine that are not emergencies but should also be reported to your doctor include: Headache or dizziness. Blurred or double vision. Dry mouth. Fatigue. Nausea. Tremor. Rash. Weight gain. Most of these side effects lessen with time. Long-term effects vary from drug to drug. In general: Pregnant women should not take anticonvulsants ...The phase IV clinical study analyzes which people take Lamotrigine and have Dizziness. It is created by eHealthMe based on reports of 61,601 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions. Phase IV trials are used to detect ...The safety of using Lamictal during pregnancy has not been established. Lamictal is secreted into breast milk, and breastfeeding while taking Lamictal is not recommended. Our Lamictal Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.Most people tolerate long-term treatment with Trileptal well and experience only mild to moderate side effects. People tend to experience the most side effects early in treatment, as the dosage is titrated up. The most commonly reported side effects are dizziness, drowsiness, changes in eyesight, upset stomach, tiredness, shaking, and headache.Aug 11, 2023 · multiple swollen and inflamed skin lesions. muscle pain or stiffness. muscle tension or tightness. normal menstrual bleeding occurring earlier, possibly lasting longer than expected. numbness of the feet, hands and around mouth. pains in the stomach, side, or abdomen, possibly radiating to the back. Mar 20, 2017 · Results. Treatment efficacy was observed at week 4, with the improved HSDS scores sustained until week 52 for all types of BP; 50% of the patients with any type of BP could be treated with LTG for 1 year, whereas ~40% could be treated for >1.5 years. However, 25% of the patients were withdrawn within the first 4 weeks. .

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